Robert Boyle Prize for Analytical Science 2012 Winner

Professor Norman Doivichi
Professor Norman Dovichi
University of Notre Dame

For pioneering development of ultrasensitive separations, including the first separations at zepto- and yoctomole levels and capillary electrophoresis-based DNA sequencing for the human genome.

About the Winner

Norman Dovichi holds the Grace-Rupley Professorship in the department of Chemistry and Biochemistry at the University of Notre Dame. He received his BSc with a dual major in Chemistry and Mathematics from Northern Illinois University and his PhD in Physical Analytical Chemistry from the University of Utah, where he was Joel Harris's first PhD student. He spent two years at Los Alamos Scientific Laboratory with Dick Keller. Since then he has held faculty positions at the Universities of Wyoming, Alberta, and Washington before taking his current position at Notre Dame.

Dovichi has graduated 57 PhD students, has published over 250 papers, holds seven US patents, and has given over 350 invited talks. He has served on the editorial advisory boards of 16 journals and now serves as Associate Editor for Analytical Chemistry. He holds an honorary professorship with the Chinese Academy of Sciences.

Dovichi has primarily focused his research on the use of capillary electrophoresis and ultrasensitive laser-induced fluorescence for analysis of minute amounts of biological molecules. In the 1980s, he introduced the concept of single molecule detection to the chemical literature. In the 1990s, his group employed that technology to measure the activity and activation energy of single enzyme molecules. His group also developed capillary array electrophoresis instruments for high-throughput DNA sequencing. This technology was patented and commercialized as the Applied Biosystems model 3700 DNA sequencer. He was recognized for this work by the journal Science as an "Unsung Hero of the Human Genome Project".

More recently, his group has focused its attention on chemical cytometry, which is the chemical analysis of the content of single cells. This chemical cytometry work has developed a suite of powerful tools for the characterization of glycosphingolipids in single neurons and glia. Most recently, his group has developed capillary electrophoresis-tandem mass spectrometry as a tool for analysis of zeptomole amounts of peptides and for characterization of the protein content of single cells.

Related Links

Link icon Professor Dovichi's Webpage
University of Notre Dame

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