George and Christine Sosnovsky Award in Cancer Therapy 2008 Winner
School of Pharmacy, University of London, UK
Awarded for his outstanding contributions to fundamental and translational research relating to telomerase targeting. In collaboration with LH Hurley (Sosnovsky award winner in 2005/2006), Professor Neidle has designed, synthesised and subsequently analysed at the atomic level potential anti-cancer drugs that target quadruplex DNA. Through the realisation that quadruplex sequences are prevalent in genomes, Professor Neidle's work has pioneered further drug development approaches involving quadruplex-binding ligands.
About the winner
Stephen Neidle is a chemistry graduate of Imperial College where he was awarded a PhD for crystallographic studies of natural products and antibiotics. After a period as an ICI Fellow, he joined the Biophysics Department at King's College, which initiated his interest in nucleic acid structural studies.
He was appointed as one of the first Cancer Research Campaign Career Development Awardees, and is now a Professorial Fellow of Cancer Research UK. He was appointed to the Chair of Biophysics at the Institute of Cancer Research in 1990 and moved to the new Chair of Chemical Biology at the School of Pharmacy, University of London in 2002, as Director of the Cancer Research UK Biomolecular Structure Group.
His interests are primarily in the chemistry and biology of nucleic acid structure and recognition by small molecules, and in exploiting this information for the rational design of new anticancer agents. Most recently he has especially studied the structure and recognition of G-quadruplex nucleic acids.
He has published nearly 400 papers and reviews, and has written and edited a number of books on nucleic acids and drug-DNA interactions. He received the 2000 prize of the Biological and Medicinal Chemistry Sector of the Royal Society of Chemistry, and its 2002 Interdisciplinary Award, and was awarded the 2004 Aventis Prize in Medicinal Chemistry of the French Societé de Chimie Thérapeutique.
Stephen Neidle's homepage
The Cancer Research UK Biomolecular Structure Group at the School of Pharmacy, UK
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