Gerhard Ecker, Editor-in-chief
University of Vienna, Austria
Gerhard received his doctorate in natural sciences from the University of Vienna and performed his post-doctoral training at the group of J. Seydel in Borstel (Germany).
Gerhard Ecker is a Professor for Pharmacoinformatics and Head of the Pharmacoinformatics Research Group at the Department of Pharmaceutical Chemistry, University of Vienna. He also coordinates the research focus “Computational Life Sciences” of the Faculty of Life Sciences.
His main research interests are ligand- and structure-based drug design with focus on transmembrane transport proteins, prediction of on- and off-kinetics, as well as semantic data integration.
Matthew Fuchter, Associate editor
Imperial College London, UK
ORCID: http://orcid.org/0000-0002-1767-7072
Matthew Fuchter is a Reader in Chemistry at the Department of Chemistry, Imperial College London. In addition, he is working group lead within the new therapeutics Theme of the Imperial College Cancer Research UK Centre. He is a research board member of the Institute of Chemical Biology, co-director of the Imperial MRes in Drug Discovery, a panel member of the Cancer Research UK Multidisciplinary Award, and an appointed member of the Royal Society of Chemistry Organic Division. He is heavily involved in medicinal chemistry, chemical biology and translational activities at Imperial and externally.
His primary research interests concern the misregulation of epigenetic events in disease, although he has made a number of contributions to other disease areas/targets.
Sylvie Garneau-Tsodikova, Associate editor
University of Kentucky, USA
Sylvie Garneau-Tsodikova obtained her PhD in Chemistry in 2003 from the University of Alberta (Professor John C Vederas). She then pursued her postdoctoral studies with Professor Christopher T Walsh at Harvard Medical School. In 2006, Sylvie joined the University of Michigan as the John G Searle Assistant Professor of Medicinal Chemistry at the College of Pharmacy and the Life Sciences Institute. In 2013, Garneau-Tsodikova relocated to the University of Kentucky as an Associate Professor of Pharmaceutical Sciences at the College of Pharmacy. She is an Associate Editor for RSC Medicinal Chemistry and a member of the Editorial Boards of Journal of Biological Chemistry and ACS Infectious Diseases. She is the recipient of numerous research and teaching awards including the Vahlteich Research Award and NSF CAREER Award as well as the UK Blouin Award. She has published >85 manuscripts and has given >60 invited talks and plenary lectures on her work in Israel, India, Jamaica, Scotland, England, Canada, China, and USA.
Christa Müller, Associate editor
Universität Bonn, Germany
ORCID: http://orcid.org/0000-0002-0013-6624
Christa Müller studied pharmacy at the University of Tübingen, Germany, and received her PhD in Pharmaceutical/Medicinal Chemistry from the same University. After a postdoctoral stay with John W. Daly at the Laboratory of Bioorganic Chemistry, National Institutes of Health (Maryland, USA) she completed her habilitation thesis at the University of Tübingen (1994), and became Associate Professor of Pharmaceutical Chemistry at Würzburg University in the same year. Müller has been Professor of Pharmaceutical Chemistry at Bonn University since 1998 and is also co-founder of the Pharma-Center Bonn. She has >300 publications in the fields of medicinal and organic chemistry and pharmacology.
Her scientific interests are focused on the medicinal chemistry and molecular pharmacology of purine-binding membrane proteins (purine receptors, ectonucleotidases) and orphan G protein-coupled receptors. Disease indications include neurodegenerative and inflammatory diseases and cancer. Her activities are ranging from basic research to collaborative drug development projects with pharma industry partners.
Sally-Ann Poulsen, Associate editor
Griffith University, Queensland, Australia
ORCID: http://orcid.org/0000-0003-4494-3687
Sally-Ann Poulsen is Professor and Deputy Director (acting) at Griffith Institute for Drug Discovery (GRIDD), Griffith University, Brisbane, Australia. She holds a PhD in medicinal chemistry also from Griffith University, receiving a University Medal for academic excellence. Immediately following her PhD she was recipient of a Royal Society & National Health and Medical Research Council (NHMRC) Howard Florey Research Fellowship to undertake research at the University of Cambridge. On returning to Australia, she was awarded an Australian Research Council QEII Fellowship, followed by an Australian Research Council Future Fellowship.
Poulsen works with collaborators in Australia and internationally, both from academia and industry on projects related to development of new chemical probes, medicinal chemistry targeting cancer and infectious disease, and fragment screening using native state mass spectrometry. Her research is defined by the application of chemistry expertise to address complex questions across biology.
Poulsen was appointed as a Fellow, Royal Australian Chemical Institute (RACI) in 2017. She is Chair elect of the RACI Medicinal Chemistry and Chemical Biology Division and is a global council member of the International Chemical Biology Society. She is author of >100 publications in the field of medicinal chemistry and chemical biology.
Christopher Burns
MetabloQ Pharmaceuticals, Melbourne, Australia
ORCID: http://orcid.org/0000-0002-4463-4916
Christopher Burns obtained his PhD in Organic Chemistry at the University of Melbourne in 1990. Following postdoctoral work at Pennsylvania State University with Professor Ken Feldman, he joined Pfizer (UK) as a medicinal chemist. After 5 years Burns returned to Australia where he worked in the field of biosensors for use in drug discovery, first as a Research Fellow at The University of Sydney, and then with biotech company Ambri. In 2001 Burns joined Melbourne biotechnology company Cytopia to establish and lead the medicinal chemistry team and in 2006 he became Research Director. Over this time Burns led the discovery of two compounds that entered clinical trial: the orally active vascular disrupting agent lexibulin and the dual JAK1/2 inhibitor momelotinib. The latter compound, now being developed by Gilead Sciences, is currently undergoing multiple Phase II and III trials. Most recently He was a Laboratory Head at the Walter and Eliza Hall Institute of Medical Research in Melbourne, and was previously Research Director at Melbourne biotech Cytopia Research and Chief Scientific Adviser at Canadian biotech YM BioSciences. He currently is CEO of MetabloQ Pharmaceuticals.
Andrea Cavalli
University of Bologna and Italian Institute of Technology, Italy
ORCID: http://orcid.org/0000-0002-6370-1176
Andrea Cavalli is Professor of Medicinal Chemistry at the University of Bologna and Head of CompuNet at the Italian Institute of Technology, Genova. He received his PhD in Pharmaceutical Sciences from the University of Bologna (1999) and did postdoctoral work at SISSA (Trieste, Italy) and ETH (Zürich, Switzerland). He is an author of more than 160 scientific articles and inventor in several international patents. He is a member of the Editorial Board of several international journals, and an Academic Editor of PLOS ONE. In 2003, he received the Farmindustria Prize for Pharmaceutical Research.
Professor Cavalli’s research combines computational chemistry with drug discovery, focusing on neurodegenerative diseases, cancer, and neglected tropical diseases. He has developed and applied computational tools and protocols to accelerate and enhance the discovery of novel lead and drug candidates. In particular, he has been a pioneer in using molecular dynamics simulations and related approaches to drug discovery. Cavalli is co-founder of a high-tech startup company (BiKi Technologies) focused on molecular dynamics and enhanced sampling in drug discovery. In an interdisciplinary effort, these approaches led to the identification and characterization of lead candidates within the framework of multitarget drug discovery and polypharmacology.
Mike Hann
GSK Medicines Research Centre, Stevenage, UK
ORCID: http://orcid.org/0000-0003-4360-9505
Mike Hann obtained his PhD in Organic Chemistry at the City University in London (1980) with Professor Peter Sammes. He then worked in the UK as a medicinal chemist at Roussel, Wyeth and GD Searle. During his time at GD Searle he had the opportunity to get involved with the emerging use of computational chemistry and molecular modelling in drug discovery. He joined GlaxoSmithKline (GSK) in 1986 as a computational chemist before becoming Head of Computational Chemistry. Later he became Director of Biomolecular Sciences for GSK with responsibilities for x-ray crystallography, biophysics and protein MS studies. His current role continues to find him at the interface of chemistry and biology and involves promoting scientific exchange, excellence and innovation to improve drug discovery methodologies within GSK and with external collaborators. He has published extensively on a wide range of subjects and is also a visiting Professor in the Department of Chemistry at Imperial College London.
Yoshinori Ikeura
Axcelead Drug Discovery Partners, Kanagawa, Japan
ORCID: http://orcid.org/0000-0003-1593-3391
Yoshinori Ikeura received a Master of Science degree in Organic Chemistry in 1986 from Kyoto University. In the same year, he joined the Medicinal Chemistry Laboratories of Takeda Pharmaceutical Company Ltd. In 1999, he earned a PhD from Kyoto University by studying of Tachykinin NK receptor antagonists and in 2000-2001 worked on natural products synthesis at MIT as a postdoctoral fellow. In 2011, he became the head of Inflammation Drug Discovery Unit at Pharmaceutical Research Division. Ikeura assumed the head of General Manager Office in 2012 and since 2015 he also holds the post of the Site Head at Shonan Research Center in Japan.
Lyn Jones
Dana-Farber Cancer Institute, Boston, USA
Lyn Jones completed PhD studies in synthetic organic chemistry at the University of Nottingham, before starting his post-doctorate research at The Scripps Research Institute, California in the area of chemical biology. In 2001, he joined Pfizer (Sandwich, UK) as a medicinal chemistry team leader. In 2011, he transferred to Cambridge, MA to become Head of Rare Disease Chemistry and to lead the Chemical Biology Group, before joining Jnana Therapeutics in 2017 as Vice President of Chemical Biology. He is currently Chief Scientist at the Center for Protein Degradation at the Dana-Farber Cancer Institute.
In 2009, he won the inaugural Royal Society of Chemistry Young Industrialist of the Year Award for his contributions to HIV and COPD research and clinical candidate delivery.
He is an author or inventor on over 100 publications and patents, a fellow of the Royal Society of Chemistry (FRSC) and the Royal Society of Biology (FRSB), and he is an elected member of the Chemistry Biology Interface Division Council of the Royal Society of Chemistry.
Jean-Louis Reymond
University of Bern, Switzerland
ORCID:https://orcid.org/0000-0003-2724-2942
Jean-Louis Reymond is a Professor of Chemistry at the University of Bern, Switzerland. He studied Chemistry and Biochemistry at the ETH Zürich and obtained his Ph.D. at the University of Lausanne on natural products synthesis (1989). After a Post-Doc and Assistant Professorship at the Scripps Research Institute, he joined the University of Bern (1997). His research focuses on the enumeration and visualization of chemical space for small molecule drug discovery, the synthesis of new molecules from GDB (http://gdb.unibe.ch), and the design and synthesis of peptide dendrimers and polycyclic peptides as antimicrobials and for nucleic acids delivery. He is the author of > 300 scientific publications and reviews.
