Dr Sarah Lovelock
Winner: 2024 Harrison-Meldola Early Career Prize for Chemistry
The University of Manchester
For the development of innovative biocatalytic approaches to produce therapeutic oligonucleotides.
Celebrate Dr Sarah Lovelock
Therapeutic oligonucleotides are a new class of RNA-based molecules that have the potential to treat a wide range of diseases. However, the rapidly growing number of therapies approved and in advanced clinical trials is placing unprecedented demands on our capacity to manufacture oligonucleotides at scale. Biocatalysis is an exciting technology that is widely used across the chemical industry: this is where enzymes are used to convert starting materials into high-value products.
Dr Lovelock’s group is developing biocatalytic approaches to produce therapeutic oligonucleotides in a more sustainable and scalable way. One strategy they have developed produces complex oligonucleotide sequences in a single operation using polymerases and endonucleases (nature’s enzymes). These enzymes work together to amplify complementary sequences embedded within a catalytic template. The group is working in partnership with industry to translate their approaches into manufacturing processes.
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