Digestibility and enteric release achieved with microencapsulates made from emulsion-templated plant proteins
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Luke Wayne Browning, Huafu Wang, James Ward Taylor, Pete Wilde, Marc Rodriguez-Garcia, Lynette Anne Makins Holland and Tuomas P. J. Knowles

Prize

Sustainable Food Technology Outstanding Early Career Researcher Award

Year

2025

Citation

Paper: Digestibility and enteric release achieved with microencapsulates made from emulsion-templated plant proteins

We have developed a novel plant protein microencapsulate containing vitamin D2 and the study described in our manuscript characterises the digestibility and controlled release of cargo throughout digestive phases. With our unique processing and oil-emulsification of pea protein, we show that robust microcapsules can be formed by spray drying with microscopic sizing that are dispersible and stable in aqueous systems under conditions relevant to beverage manufacture. Importantly, our production process does not negatively impact the digestibility of the microcapsules, and it promotes a favourable digestion profile for the enteric release of the vitamin D2 cargo.

Employing the static in vitro INFOGEST digestion model, we examined the disintegration of microcapsules throughout digestive phases whilst quantifying release of vitamin D2 cargo by HPLC simultaneously. Our results demonstrate that these microcapsules exhibit resilience in the oral and gastric phases and are completely susceptible to the intestinal phase, thereby delivering the cargo to the site where small molecules, such as vitamins, are effectively absorbed. This novel encapsulate addresses the growing need for robust microcapsules made from natural, biodegradable and edible materials.

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About the winners

Luke Browning smiling wearing a blue gingham patterned button-down shirt.

Luke Browning works as Senior Protein Scientist for Xampla, following a PhD and Post-doc at Department of Plant Sciences, University of Cambridge, and two years in industry as a manufacturing and QC scientist. His background and research themes have included the detection, quantification and characterisation of various plant proteins in fundamental, agricultural and biomaterials contexts. At Xampla, he leads on ways to extract and manipulate the physico-chemical properties of plant proteins from a variety of sources for producing biodegradable microcapsules, films and coatings.

Huafu Wang smiling, wearing glasses and a light blue patterned button-up shirt, set against a softly blurred green background.

Huafu Wang worked as a Senior Analytical Chemist for Xampla. From a background in chemistry and biochemistry, he has extensive experience in analytical method development and validation for beverage, food and pharmaceutical sectors. His role in this paper involved HPLC analyses for vitamin D.

James Ward Taylor smiling, wearing a graphic-print button-down shirt against a softly blurred green background.

James Ward Taylor works as Innovation Manager for Xampla, following a PhD at the University of Glasgow, and a Post-doc at Radboud University, Nijmegen. From a background in physical organic chemistry and self-assembly of soft matter, he researches new ways to control the self-assembly of proteins and other biomolecules to produce edible, biodegradable microcapsules, films and coatings. His role in this paper was in the microencapsulation process, using Xampla’s technology to effectively encapsulate vitamin D, and demonstrating its controlled release properties.

Professor Pete Wilde smiling with short grey hair and a blue button-up shirt, set against a plain white background.

Professor Pete Wilde is an Emeritus Fellow of Quadram Institute. His early research focused on the interfacial properties of proteins and their role in food functionality such as foams and emulsions. Later, his research investigated how food microstructure changes during digestion and how this influences nutrient absorption, satiety, and metabolic health. He has a broad interest in how food structure impacts health outcomes, including obesity and type 2 diabetes, and how digestion can be modulated to improve physiological responses. He has published over 135 papers, delivered invited international lectures, and holds editorial and honorary academic positions in the field of food science.

Marc Rodriguez-Garcia is Xampla’s co-founder, having developed the technology with Professor Knowles at the University of Cambridge. With a PhD from the University of Glasgow, his expertise lies in the use of natural biopolymers in microencapsulation and other structured materials. Marc is a unique CTO with incredible scientific knowledge combined with strong commercial acumen. 

Lynette Holland smiling, wearing a blue and white patterned blouse, set against a soft, blurred natural green background.

Lynette Holland is Principal Scientist at Xampla, developing natural biodegradable fragrance encapsulates using plant polymers. Lynette has over 20 years of R&D experience in the fragrance industry previously developing fragrance delivery systems at Procter & Gamble and Coty, with over 40 patent filings. She leads the encapsulation technology development at Xampla and manages the IP portfolio.

Professor Tuomas Knowles smiling, wearing a dark suit jacket over a light blue button-down shirt in front of a green, leafy outdoor background.

Professor Tuomas Knowles is Board Scientific Advisor at Xampla, and the co-founder of three other Cambridge University spin-outs, Fluidic Analytics, Wren Therapeutics and Transition Bio. Professor Knowles has received a number of distinguished awards, including the Corday-Morgan Prize from the Royal Society of Chemistry and the Raymond and Beverly Sackler International Prize in Biophysics.

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