Electrochemical oxidation at carbon paste electrode of tacrine and 1-hydroxytacrine and differential pulse voltammetric determination of tacrine in pharmaceuticals and human urine
Abstract
The electrochemical oxidation of tacrine and its 1-OH-metabolite, has been studied by cyclic voltammetry and differential pulse voltammetry by using carbon paste electrodes. The peak current–concentration relationship was found to be linear up to 20 μg ml−1 with detection limits of 0.06 μg ml−1 for tacrine and 0.18 μg ml−1 for 1-OH-tacrine and quantitation limits of 0.20 μg ml−1 for tacrine and 0.37 μg ml−1 for 1-OH-tacrine. A method for determining tacrine by differential pulse voltammetry in pharmaceuticals and human urine, in the presence of 1-OH-tacrine, has been developed.
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