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Publishing frequency: 12 issues per year
Indexed in MEDLINE
Chair: Tobias Gulder
Scope
Natural Product Reports (NPR) is a critical review journal that stimulates progress in all areas of natural products research, including isolation, structural and stereochemical determination, biosynthesis, biological activity and synthesis.
The scope of the journal is very broad, and many reviews discuss the role of natural products in the wider bioinorganic, bioorganic and chemical biology communities. Areas covered include the following:
- Enzymology
- Nucleic acids
- Genetics
- Chemical ecology
- Carbohydrates
- Primary and secondary metabolism
- Analytical techniques
NPR articles are designed to give an interesting insight into the topic, focussing on the key developments that have shaped a field rather than giving a very comprehensive overview of all results.
Authors are encouraged to include their own perspective on developments, trends and future directions.
Chair
Tobias Gulder, Technical University of Dresden, Germany
Editorial board members
Giovanni Appendino, Universita del Piemonte Orientale, Italy
Mark Brönstrup, Helmholtz Centre for Infection Research, Braunschweig, Germany
Nadja Cech, University of North Carolina, Greensboro, USA
Olga Genilloud, Fundación MEDINA, Spain
Hendrik Luesch, University of Florida, USA
Marnix Medema, Wageningen University, Netherlands
Dong-Chan Oh, Seoul National University, South Korea
Janet Smith, University of Michigan, USA
Eriko Takano, University of Manchester, UK
Christopher Vanderwal, University of California, Irvine, USA
Zhen Yang, Peking University, China
Changsheng Zhang, South China Sea Institute of Oceanology, China Academy of Sciences, China
Mike Beale, Rothamsted Research, Harpenden, UK
Carole Bewley, National Institutes of Health, USA
Christopher Boddy, University of Ottawa, Canada
Vanderlan da Silva Bolzani, Universidade Estadual Paulista, Brazil
Robert Britton, Simon Fraser University, Canada
Margaret A Brimble, University of Auckland, New Zealand
Timothy D H Bugg, University of Warwick, UK
Guy Carter, Carter-Bernan Consulting, New City, NY, USA
Russell Cox, Leibniz Universität Hannover, Germany
Pieter Dorrestein, University of California, San Diego, USA
Robert A Field, Manchester Institute of Biotechnology, UK
Rajesh Gokhale, Institute of Genomics & Integrative Biology, Delhi, India
Rebecca Goss, St. Andrews University, UK
Alan Harvey, University of Strathclyde, UK
Seth Herzon, Yale University, USA
Chambers Hughes, University of Tuebingen, Germany
Masayuki Inoue, University of Tokyo, Japan
David Jakeman, Dalhousie University, Canada
Marcel Jaspars, University of Aberdeen, UK
Martin Kaltenpoth, Johannes Gutenberg University Mainz, Germany
David G I Kingston, Virginia Tech, USA
Andreas Kirschning, University of Hannover, Germany
Harold Kohn, University of North Carolina, USA
Julia Kubanek, Georgia Institute of Technology, USA
Finian J Leeper, University of Cambridge, UK
Wen Liu, Shanghai Institute of Organic Chemistry, China
Sandra Loesgen, University of Florida, USA
Dawei Ma, Shanghai Institute of Organic Chemistry, China
John Mann, Queen's University Belfast, UK
Michio Murata, Osaka University, Japan
Bastien Nay, Muséum National d'Histoire Naturelle, CNRS, France
Sarah O'Connor, Max Planck Institute for Chemical Ecology, Jena, Germany
David O'Hagan, University of St Andrews, UK
Andrew Phillips, Yale University, USA
Jörn Piel, ETH Zurich, Switzerland
Georg Pohnert, Friedrich Schiller University of Jena, Germany
Emma Raven, University of Bristol, UK
Jürgen Rohr, University of Kentucky, USA
Martin Schmeing, McGill University, Canada
Christopher J Schofield, University of Oxford, UK
Stefan Schulz, TU Braunschweig, Germany
Michael Sherburn, Australia National University, Australia
Thomas J Simpson, University of Bristol, UK
Sheo Singh, Merck & Co., Rahway, USA
Renxiang Tan, Nanjing University, China
Dirk Trauner, Ludwig-Maximilian University Munich, Germany
John C Vederas, University of Alberta, Canada
Clay Wang, University of Southern California, USA
Kira Weissman, Lorraine University, France
Craig Williams, The University of Queensland, Australia
Yeo Joon Yoon, Seoul National University, Korea
Katie Lim, Executive Editor, ORCID 0000-0001-9052-1317
James Anson, Deputy Editor
Catherine Hodges, Development Editor
Viktoria Titmus, Editorial Production Manager
Nicola Burton, Publishing Editor
Roxane Owen, Publishing Editor, ORCID 0000-0002-4553-233X
Alex Rowles, Publishing Editor
Donna Smith, Publishing Editor
Quyen Ngo, Editorial Assistant
Andrea Whiteside, Publishing Assistant
Journal specific guidelines
The following guidelines are journal specific. For general guidance on preparing an article please visit our Prepare your article page, the content of which is relevant to all of our journals.
Guidelines on writing titles, abstracts & table of contents information
The title, abstract and graphical abstract are the first parts of your manuscript that editors, referees and potential readers will see, and once published they play a major part in a researcher’s decision to read your article. Therefore it’s important that these clearly and concisely summarise the topic of your review and its significance.
Title
The title should be short and straightforward to appeal to a general reader, but detailed enough to properly reflect the contents of your review article.
- Keep it relatively short – between 8 and 15 words is ideal.
- Use easily recognisable words and phrases that can be read quickly.
- Use general or well-known terms for compounds and procedures rather than very specialised terms or nomenclature.
- Avoid using non-standard abbreviations and symbols.
- Use keywords and familiar, searchable terms – these can increase the chances of your article appearing in search results. Around 70% of our readers come directly via search engines.
Abstract
The abstract is a single paragraph which summarises the contents of your article. It will help readers to decide whether your article is of interest to them.
- The length can vary from 50 to 250 words (or up to 100 words for Highlight articles), but it should always be concise and easy to read with recognisable words and phrases.
- It should summarise the research area that your review covers, including why it is important.
- Like your title, make sure you use familiar, searchable terms and keywords.
Table of contents information
This consists of a small graphic and short text which will appear in the table of contents and feeds (for example, RSS feeds).
The graphic should:
- be 8 cm wide x 4 cm high
- be a clear representation of what your review is about. Think about what would grab the attention of a reader as they scan though article listings. For example, for synthetic reviews a representative target compound or key reaction scheme work well
- include only one or two key elements (as the graphics are small). It’s much better to have a small amount of information that stands out rather than a lot of information which is too small to understand
- avoid using graphs or spectra
- include text large enough to read and in Arial, Times or Helvetica font
- avoid reusing figures from the article
The text should:
- be a maximum of 20 words
- give a clear indication of the topic discussed in the review and, where possible, why it is important. Again, think about what would grab the attention of the potential reader and would encourage them to read the full article
- use easily recognisable words and phrases that can be read quickly
- not just repeat the information given in the title
Titles
Chemical proteomics approaches for identifying the cellular targets of natural products
From DOI: 10.1039/C6NP00001K
Dereplication, sequencing and identification of peptidic natural products: from genome mining to peptidogenomics to spectral networks
From DOI: 10.1039/C5NP00050E
A twist of nature – the significance of atropisomers in biological systems
From DOI: 10.1039/C4NP00121D
Abstracts
This highlight provides an overview of recent progress towards elucidating the structure, biosynthesis, and mode of action of colibactin, a genotoxic secondary metabolite synthesized by human gut bacteria. While isolating colibactin has been problematic, efforts to characterize its biosynthesis have provided critical information that has led to a rapid increase in our knowledge of this metabolite's structure and function. Major questions and gaps remain however, and the broader lessons learned from studying colibactin underscore central challenges to be faced in the genomics era of natural product research and in efforts to understand the human microbiome.
From DOI: 10.1039/C5NP00091B
Deconvoluting the mode of action of natural products and drugs remains one of the biggest challenges in chemistry and biology today. Chemical proteomics is a growing area of chemical biology that seeks to design small molecule probes to understand protein function. In the context of natural products, chemical proteomics can be used to identify the protein binding partners or targets of small molecules in live cells. Here, we highlight recent examples of chemical probes based on natural products and their application for target identification. The review focuses on probes that can be covalently linked to their target proteins (either via intrinsic chemical reactivity or via the introduction of photocrosslinkers), and can be applied “in situ” – in living systems rather than cell lysates. We also focus here on strategies that employ a click reaction, the copper-catalysed azide–alkyne cycloaddition reaction (CuAAC), to allow minimal functionalisation of natural product scaffolds with an alkyne or azide tag. We also discuss ‘competitive mode’ approaches that screen for natural products that compete with a well-characterised chemical probe for binding to a particular set of protein targets. Fuelled by advances in mass spectrometry instrumentation and bioinformatics, many modern strategies are now embracing quantitative proteomics to help define the true interacting partners of probes, and we highlight the opportunities this rapidly evolving technology provides in chemical proteomics. Finally, some of the limitations and hallenges of chemical proteomics approaches are discussed.
From DOI: 10.1039/C6NP00001K
While recent breakthroughs in the discovery of peptide antibiotics and other Peptidic Natural Products (PNPs) raise a challenge for developing new algorithms for their analyses, the computational technologies for high-throughput PNP discovery are still lacking. We discuss the computational bottlenecks in analyzing PNPs and review recent advances in genome mining, peptidogenomics, and spectral networks that are now enabling the discovery of new PNPs via mass spectrometry. We further describe the connections between these advances and the new generation of software tools for PNP dereplication, de novo sequencing, and identification.
From DOI: 10.1039/C5NP00050E
Table of contents
In this Viewpoint article we examine the roles of bacterially produced small molecules in animal defense, development and evolution.
From DOI: 10.1039/C4NP00141A
This highlight reviews recent studies of colibactin, a structurally uncharacterized genotoxin synthesised by members of the human gut microbiota.
From DOI: 10.1039/C5NP00091B
This highlight focuses on one of Nature's key strategies to doubly modify an amino acid during nonribosomal peptide biosynthesis by using a single enzyme, an interrupted adenylation domain.
From DOI: 10.1039/C4NP00120F
Readership information
Academic and industrial scientists working in all areas of natural products research and wider topics including chemical biology, organic synthesis, pharmacology and analytical chemistry.
Subscription information
Natural Product Reports is part of the collection RSC Gold
Online only 2021: ISSN 1460-4752, £1,098 / $1,932
*2019 Journal Citation Reports (Clarivate Analytics, 2020)
NPR
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