Issue 0, 1973

Steroids and related studies. Part XX. 4,17a-Diaza-D-homo-steroids

Abstract

Oxidation of 17a-aza–D-homoandrost-4-ene-3,17-dione with sodium periodate–potassium permanganate yields 5,17-dioxo-l7a-aza-;D-homo-A-nor-3,5-secoandrostan-3-oic acid which has been used to prepare some 4,17a-diaza-D-homo-steroids. We report the synthesis of 4,17a-dimethyl-4,17a-diaza–D-homo-5α-androstane dimethiodide (HS-342), which possesses neuromuscular-blocking activity.

Article information

Article type
Paper

J. Chem. Soc., Perkin Trans. 1, 1973, 1204-1206

Steroids and related studies. Part XX. 4,17a-Diaza-D-homo-steroids

H. Singh, D. Paul and V. V. Parashar, J. Chem. Soc., Perkin Trans. 1, 1973, 1204 DOI: 10.1039/P19730001204

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