Issue 4, 2010
From the journal:

Analyst

Molecularly imprinted polymers as analyte sequesters and selective surfaces for easy ambient sonic-spray ionization†

Eduardo Costa Figueiredo,*ab   Gustavo Braga Sanvido,b   Marco Aurélio Zezzi Arrudacd  and  Marcos Nogueira Eberlinb  

* Corresponding authors

a Department of Clinical and Toxicological Analysis, Federal University of Alfenas - UNIFAL-MG, Street Gabriel Monteiro da Silva, 714, Alfenas, MG, Brazil
E-mail: eduardocfig@yahoo.com.br
Fax: +55 19 3299 1063
Tel: +55 35 3299 1224

b ThoMSon Mass Spectrometry Laboratory, Institute of Chemistry, University of Campinas - UNICAMP, P.O. Box 6154, Campinas, SP, Brazil

c Group of Spectrometry, Sample Preparation and Mechanization - GEPAM, Institute of Chemistry, University of Campinas - UNICAMP, P.O. Box 6154, Campinas, SP, Brazil

d National Institute of Science and Technology for Bioanalytics, Institute of Chemistry, University of Campinas - UNICAMP, P.O. Box 6154, Campinas, SP, Brazil

Abstract

The use of a molecularly imprinted polymer (MIP) as a selective surface for ambient mass spectrometry is demonstrated. The MIP is used to sequester target analytes from urine and easy ambient sonic-spray ionization mass spectrometry (EASI-MS) is shown to be able to efficiently desorb the analytes from the MIP surface and then transfer them in protonated forms to the gas phase for MS analysis. A set of five phenothiazines (chlorpromazine, perphenazine, triflupromazine, thioridazine and prochlorperazine) were chosen from a proof-of-principle class of drug samples. A chlorpromazine-imprinted methacrylic polymer was synthesized and used to prepare a MIP probe. The MIP-EASI-MS technique using acidified methanol as solvent has been shown to allow quantification of all five drugs in urine with LOQ of ca. 1 μmol L−1.

Graphical abstract: Molecularly imprinted polymers as analyte sequesters and selective surfaces for easy ambient sonic-spray ionization

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Article information

DOI
https://doi.org/10.1039/B923289C
Article type
Paper
Submitted
06 Nov 2009
Accepted
13 Dec 2009
First published
11 Jan 2010

Analyst, 2010,135, 726-730

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Molecularly imprinted polymers as analyte sequesters and selective surfaces for easy ambient sonic-spray ionization

E. C. Figueiredo, G. B. Sanvido, M. A. Zezzi Arruda and M. N. Eberlin, Analyst, 2010, 135, 726 DOI: 10.1039/B923289C

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