Issue 2, 1992

Synthesis of carboranes containing nucleoside bases. Unexpectedly high cytostatic and cytocidal toxicity towards cancer cells

Abstract

5-Carboranyluridine 1, 5-carboranyldeoxyuridine 2 and 5-hydroxymethylcarboranyluridine 3 have been prepared; they show unexpectedly high cytotoxicity towards cancer cells, with IC50 values being ca. 10–5 mol dm–3.

Article information

Article type
Paper

J. Chem. Soc., Chem. Commun., 1992, 157-158

Synthesis of carboranes containing nucleoside bases. Unexpectedly high cytostatic and cytocidal toxicity towards cancer cells

Y. Yamamoto, T. Seko, H. Nakamura, H. Nemoto, H. Hojo, N. Mukai and Y. Hashmioto, J. Chem. Soc., Chem. Commun., 1992, 157 DOI: 10.1039/C39920000157

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