Issue 5, 2004
From the journal:

Chemical Communications

Reactive barium-promoted Reformatsky-type reaction of α-chloroketones with aldehydes

Akira Yanagisawa,*a   Hiroshi Takahashib  and  Takayoshi Araia  

* Corresponding authors

a Department of Chemistry, Faculty of Science, Chiba University, Inage, Chiba 263-8522, Japan
E-mail: ayanagi@scichem.s.chiba-u.ac.jp

b Graduate School of Science and Technology, Chiba University, Inage, Chiba 263-8522, Japan

Abstract

A Reformatsky-type aldol reaction of α-chloroketones with aldehydes has been achieved using reactive barium as a low-valent metal in THF; this one-pot process is more effective for obtaining the desired β-hydroxy ketones in high yields than the stepwise process in which barium enolates are prepared prior to the reaction with aldehydes.

Graphical abstract: Reactive barium-promoted Reformatsky-type reaction of α-chloroketones with aldehydes

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Article information

DOI
https://doi.org/10.1039/B314752P
Article type
Communication
Submitted
14 Nov 2003
Accepted
14 Jan 2004
First published
03 Feb 2004

Chem. Commun., 2004, 580-581

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Reactive barium-promoted Reformatsky-type reaction of α-chloroketones with aldehydes

A. Yanagisawa, H. Takahashi and T. Arai, Chem. Commun., 2004, 580 DOI: 10.1039/B314752P

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