Issue 42, 2008
From the journal:

Chemical Communications

Binding enhancement of antigen-functionalized PEGylated gold nanoparticles onto antibody-immobilized surface by increasing the functionalized antigen using α-sulfanyl-ω-amino-PEG†

Keitaro Yoshimoto,abc   Yuki Hoshino,a   Takehiko Ishii‡d  and  Yukio Nagasaki*abcef  

* Corresponding authors

a Graduate School of Pure and Applied Sciences, University of Tsukuba, Tennoudai 1-1-1, Tsukuba, Ibaraki, Japan

b Center for Tsukuba Advanced Research Alliance (TARA), University of Tsukuba, Tennoudai 1-1-1, Tsukuba, Ibaraki, Japan

c Tsukuba Research Center for Interdisciplinary Materials Science (TIMS), University of Tsukuba, Tennoudai 1-1-1, Tsukuba, Japan

d Department of Materials Science and Technology, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba, Japan

e Masters School of Medical Science, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tennoudai 1-1-1, Tsukuba, Ibaraki, Japan

f Satellite Laboratory, International Center for Materials Nanoarchitectonics (MANA), National Institute of Materials Science (NIMS), Sengen 1-2-1, Tsukuba, Japan
E-mail: nagasaki@nagalabo.jp
Fax: 81-029-853-5749
Tel: 81-029-853-5749

Abstract

We established a technique for constructing PEGylated gold nanoparticles (GNP) that have small compounds with almost complete functionalities on their surfaces using a newly synthesized hetero-telechelic poly(ethylene glycol) (PEG), and their association/dissociation behavior on an antibody-immobilized surface was evaluated using a surface plasmon resonance (SPR) sensor.

Graphical abstract: Binding enhancement of antigen-functionalized PEGylated gold nanoparticles onto antibody-immobilized surface by increasing the functionalized antigen using α-sulfanyl-ω-amino-PEG

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Article information

DOI
https://doi.org/10.1039/B811818C
Article type
Communication
Submitted
10 Jul 2008
Accepted
13 Aug 2008
First published
16 Sep 2008

Chem. Commun., 2008, 5369-5371

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Binding enhancement of antigen-functionalized PEGylated gold nanoparticles onto antibody-immobilized surface by increasing the functionalized antigen using α-sulfanyl-ω-amino-PEG

K. Yoshimoto, Y. Hoshino, T. Ishii and Y. Nagasaki, Chem. Commun., 2008, 5369 DOI: 10.1039/B811818C

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