Issue 46, 2009
From the journal:

Chemical Communications

Discovery of hydrolytic catalysts in a peptidocalixarene library by binding assay with a transition state analogue for the hydrolysis†

Hideaki Hioki,*a   Ryosuke Nishimoto,a   Kota Kawaguchi,a   Miwa Kubo,a   Kenichi Haradaa  and  Yoshiyasu Fukuyamaa  

* Corresponding authors

a Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Yamashiro-cho, Tokushima 770-8514, Japan
E-mail: hioki@ph.bunri-u.ac.jp
Fax: +81 88 655 3051
Tel: +81 88 602 8437

Abstract

Hydrolytic catalysts were found in a peptidocalixarene library by binding assay with a transition state analogue for the hydrolysis. The rate of the reaction can be specifically enhanced up to 50-fold in the presence of the discovered catalyst.

Graphical abstract: Discovery of hydrolytic catalysts in a peptidocalixarene library by binding assay with a transition state analogue for the hydrolysis

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Article information

DOI
https://doi.org/10.1039/B913907A
Article type
Communication
Submitted
13 Jul 2009
Accepted
05 Oct 2009
First published
15 Oct 2009

Chem. Commun., 2009, 7194-7196

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Discovery of hydrolytic catalysts in a peptidocalixarene library by binding assay with a transition state analogue for the hydrolysis

H. Hioki, R. Nishimoto, K. Kawaguchi, M. Kubo, K. Harada and Y. Fukuyama, Chem. Commun., 2009, 7194 DOI: 10.1039/B913907A

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