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Article citation: Jonathan Hopewell, Chem. Commun., 2010, DOI: 10.1039/b916359j

Subtleties in asymmetric catalyst structure: the resolution of a 6-phospha-2,4,8-trioxa-adamantane and its applications in asymmetric hydrogenation catalysis

Jonathan Hopewell, Piotr Jankowski, Claire L. McMullin, A. Guy Orpen and Paul G. Pringle

An efficient, classical resolution of the versatile P-ligand intermediate 6-phospha-2,4,8-trioxa-adamantane (CgPH) is described and the rhodium complex of the optically pure secondary phosphine -CgPH is an active and moderately selective asymmetric hydrogenation catalyst.

Graphical abstract image for this article (ID: b916359j)