Issue 48, 2007
From the journal:

Physical Chemistry Chemical Physics

Permeability of silk microcapsules made by the interfacial adsorption of protein†

Kevin D. Hermanson,a   Markus B. Harasim,a   Thomas Scheibel*b  and  Andreas R. Bausch*a  

* Corresponding authors

a Technische Universität München, Lehrstuhl für Biophysik, E22, James-Franck-Str. 1, Garching, Germany
E-mail: abausch@ph.tum.de

b Technische Universität München, Lehrstuhl für Biotechnologie, Lichtenbergstr. 4, Garching, Germany
E-mail: thomas.scheibel@ch.tum.de

Abstract

The assembly of colloidal particles at a liquid/liquid interface is a useful technique for the formation of a large variety of structures. Recently, we created a new method which uses liquid/liquid interfaces to assemble recombinant silk proteins into thin-shelled microcapsules. These microcapsules are mechanically stable and well suited to applications such as enzyme therapy and artificial cells. In this paper the permeability properties of these microcapsules are investigated using a novel measurement technique. It is found that the microcapsules are polydisperse in their permeabilities, but for all measured microcapsules the permeability is in the range required to protect encapsulants from immunoglobulin proteins, while allowing small molecules to enter the capsule freely.

Graphical abstract: Permeability of silk microcapsules made by the interfacial adsorption of protein

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Article information

DOI
https://doi.org/10.1039/B709808A
Article type
Paper
Submitted
28 Jun 2007
Accepted
23 Oct 2007
First published
07 Nov 2007

Phys. Chem. Chem. Phys., 2007,9, 6442-6446

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Permeability of silk microcapsules made by the interfacial adsorption of protein

K. D. Hermanson, M. B. Harasim, T. Scheibel and A. R. Bausch, Phys. Chem. Chem. Phys., 2007, 9, 6442 DOI: 10.1039/B709808A

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