Issue 28, 2008
From the journal:

Physical Chemistry Chemical Physics

Bi-analyte SERS with isotopically edited dyes

E. Blackie,*ab   E. C. Le Ru,ab   M. Meyer,ab   M. Timmer,bc   B. Burkett,b   P. Northcoteb  and  P. G. Etchegoinab  

* Corresponding authors

a The MacDiarmid Institute for Advanced Materials and Nanotechnology, Victoria University of Wellington, PO Box 600, Wellington, New Zealand

b School of Chemical and Physical Sciences, Victoria University of Wellington, PO Box 600, Wellington, New Zealand

c The Malaghan Institute of Medical Research, PO Box 7060, Wellington, New Zealand

Abstract

Isotopically substituted rhodamine dyes provide ideal probes for the study of single-molecule surface enhanced Raman scattering (SM-SERS) events through multiple-analyte techniques. Isotopic editing should, in principle, provide probes that have identical chemical properties (and surface chemistries); while exhibiting at the same time distinct Raman features which enable us to identify single-molecule SERS events. We present here a specific example of two-analyte SM-SERS based on the isotopic substitution of a methyl ester rhodamine dye. The dyes are carefully characterized (in both standard and SERS conditions) to confirm experimentally their similar chemical properties. We then demonstrate their utility for bi-analyte SERS (BiASERS) experiments and, as an example, highlight the transition from a single, to a few, to many molecules in the statistics of SM-SERS signals.

Graphical abstract: Bi-analyte SERS with isotopically edited dyes

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Article information

DOI
https://doi.org/10.1039/B803738H
Article type
Paper
Submitted
04 Mar 2008
Accepted
21 Apr 2008
First published
03 Jun 2008

Phys. Chem. Chem. Phys., 2008,10, 4147-4153

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Bi-analyte SERS with isotopically edited dyes

E. Blackie, E. C. Le Ru, M. Meyer, M. Timmer, B. Burkett, P. Northcote and P. G. Etchegoin, Phys. Chem. Chem. Phys., 2008, 10, 4147 DOI: 10.1039/B803738H

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