Issue 27, 2008
From the journal:

Dalton Transactions

Double-strand DNA cleavage from photodecarboxylation of (μ-oxo)diiron(iii) l-histidine complex in visible light†

Mithun Roy,a   Tuhin Bhowmick,b   Suryanarayanarao Ramakumar,b   Munirathinam Nethajia  and  Akhil R. Chakravarty*a  

* Corresponding authors

a Department of Inorganic and Physical Chemistry, Indian Institute of Science, Bangalore, India
E-mail: arc@ipc.iisc.ernet.in
Fax: +91-80-23600683
Tel: +91-80-22932533

b Bioinformatics Centre, Department of Physics, Indian Institute of Science, Bangalore, India

Abstract

The oxo-bridged diiron(III) complex [{Fe(L-his)(dpq)}2(μ-O)]2+ having L-histidine (L-his) and dipyrido[3,2-d:2′,3′-f]quinoxaline (dpq) bound to Fe(III) exemplifies an iron-based model photonuclease that shows visible light-induced DNA double-strand cleavage in a photodecarboxylation pathway and models iron–bleomycin activity.

Graphical abstract: Double-strand DNA cleavage from photodecarboxylation of (μ-oxo)diiron(iii) l-histidine complex in visible light

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Article information

DOI
https://doi.org/10.1039/B802533A
Article type
Communication
Submitted
13 Feb 2008
Accepted
02 May 2008
First published
23 May 2008

Dalton Trans., 2008, 3542-3545

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Double-strand DNA cleavage from photodecarboxylation of (μ-oxo)diiron(III) L-histidine complex in visible light

M. Roy, T. Bhowmick, S. Ramakumar, M. Nethaji and A. R. Chakravarty, Dalton Trans., 2008, 3542 DOI: 10.1039/B802533A

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