Volume 120, 2002
From the journal:

Faraday Discussions

Synchronization of glycolytic oscillations in a yeast cell population

Sune Danø,ab   Finn Hynne,ab   Silvia De Monte,c   Francesco d'Ovidio,c   Preben Graae Sørensenab  and  Hans Westerhoffd  

a Department of Chemistry, H. C. Ørsted Institute, Uniersity of Copenhagen, Uniersitetsparken 5, Denmark

b Center for Chaos and Turbulence Studies (CATS), H. C. Ørsted Institute, Uniersity of Copenhagen, Uniersitetsparken 5, Denmark

c Department of Physics, Technical Uniersity of Denmark, Building 309, Denmark

d Mathematical Biochemistry and Molecular Cell Physiology, BioCentum Faculty of Biology, Free Uniersity, The Netherlands

Abstract

The mechanism of active phase synchronization in a suspension of oscillatory yeast cells has remained a puzzle for almost half a century. The difficulty of the problem stems from the fact that the synchronization phenomenon involves the entire metabolic network of glycolysis and fermentation, and consequently it cannot be addressed at the level of a single enzyme or a single chemical species. In this paper it is shown how this system in a CSTR (continuous flow stirred tank reactor) can be modelled quantitatively as a population of Stuart–Landau oscillators interacting by exchange of metabolites through the extracellular medium, thus reducing the complexity of the problem without sacrificing the biochemical realism. The parameters of the model can be derived by a systematic expansion from any full-scale model of the yeast cell kinetics with a supercritical Hopf bifurcation. Some parameter values can also be obtained directly from analysis of perturbation experiments. In the mean-field limit, equations for the study of populations having a distribution of frequencies are used to simulate the effect of the inherent variations between cells.

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Article information

DOI
https://doi.org/10.1039/B103238K
Article type
Paper
Submitted
10 Apr 2001
First published
23 Nov 2001

Faraday Discuss., 2002,120, 261-275

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Synchronization of glycolytic oscillations in a yeast cell population

S. Danø, F. Hynne, S. De Monte, F. d'Ovidio, P. G. Sørensen and H. Westerhoff, Faraday Discuss., 2002, 120, 261 DOI: 10.1039/B103238K

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