Issue 42, 2009
From the journal:

Journal of Materials Chemistry

Template-free synthesis of biodegradable nanogels with tunable sizes as potential carriers for drug delivery

Juan Wu,a   Xi-Qiu Liu,b   Yu-Cai Wanga  and  Jun Wang*b  

* Corresponding authors

a Department of Polymer Science and Engineering, University of Science and Technology of China, Hefei, Anhui 230026, P.R. China

b Hefei National Laboratory for Physical Sciences at Microscale and School of Life Sciences, University of Science and Technology of China, Hefei, Anhui 230027, P.R. China
E-mail: jwang699@ustc.edu.cn
Fax: +86 551 360 0402

Abstract

Biodegradable nanogels with tunable sizes, synthesized by a template-free method, as potential carriers for drug delivery are reported. The nanogels are obtained by crosslinking thermo-induced nanoparticles, with subsequent swelling at low temperatures, which were based on a thermosensitive and biocompatible triblock copolymer composed of poly(ethylene glycol) and poly(ethyl ethylene phosphate). The nanogels loaded with doxorubicin are efficiently taken up by A549 tumor cells and the drug could be released intracellularly, demonstrated by flow cytometric analyses and confocal laser scanning microscope observations. It results in enhanced growth inhibition activity to tumor cells in comparison with free doxorubicin treatment. These polyphosphoester and poly(ethylene glycol) based nanogels are biocompatible and biodegradable, rendering potential for drug delivery applications.

Graphical abstract: Template-free synthesis of biodegradable nanogels with tunable sizes as potential carriers for drug delivery

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Article information

DOI
https://doi.org/10.1039/B908768K
Article type
Paper
Submitted
05 May 2009
Accepted
20 Aug 2009
First published
16 Sep 2009

J. Mater. Chem., 2009,19, 7856-7863

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Template-free synthesis of biodegradable nanogels with tunable sizes as potential carriers for drug delivery

J. Wu, X. Liu, Y. Wang and J. Wang, J. Mater. Chem., 2009, 19, 7856 DOI: 10.1039/B908768K

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