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Microfluidic & nanofluidic technologies for chemistry, physics, biology, and bioengineering
Paper
Lab Chip, 2006, 6, 422 - 426, DOI: 10.1039/b512576f
Microfluidic sorting system based on optical waveguide integration and diode laser bar trapping
Robert W. Applegate Jr., Jeff Squier, Tor Vestad, John Oakey, David W. M. Marr, Philippe Bado, Mark A. Dugan and Ali A. Said
Effective methods for manipulating, isolating and sorting cells and particles are essential for the development of microfluidic-based life science research and diagnostic platforms. We demonstrate an integrated optical platform for cell and particle sorting in microfluidic structures. Fluorescent-dyed particles are excited using an integrated optical waveguide network within micro-channels. A diode-bar optical trapping scheme guides the particles across the waveguide/micro-channel structures and selectively sorts particles based upon their fluorescent signature. This integrated detection and separation approach streamlines microfluidic cell sorting and minimizes the optical and feedback complexity commonly associated with extant platforms.
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