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Molecular BioSystems

Research at the interface between chemistry and the -omic sciences and systems biology.



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Communication

Mol. BioSyst., 2009, 5, 927 - 930, DOI: 10.1039/b903036k

Identification of 3-hydroxy-2-(3-hydroxyphenyl)-4H-1-benzopyran-4-ones as isoform-selective PKC- inhibitors and potential therapeutics for psychostimulant abuse

Langtian Yuan, Jin-Soo Seo, Nam Sook Kang, Shahar Keinan, Sarah E. Steele, Gregory A. Michelotti, William C. Wetsel, David N. Beratan, Young-Dae Gong, Tong H. Lee and Jiyong Hong

From a screen of small molecule libraries to identify potential therapeutics for psychostimulant abuse, 3-hydroxy-2-(3-hydroxyphenyl)-4H-1-benzopyran-4-ones were shown to be isoform-selective PKC- inhibitors.

Graphical abstract image for this article (ID: b903036k)