Issue 1, 2004
From the journal:

Organic & Biomolecular Chemistry

Synthetic anisomycin analogues activating the JNK/SAPK1 and p38/SAPK2 pathways

Edward M. Rosser,a   Simon Morton,b   Kate S. Ashton,a   Philip Cohen*b  and  Alison N. Hulme*a  

* Corresponding authors

a School of Chemistry, The University of Edinburgh, West Mains Road, Edinburgh, UK
E-mail: Alison.Hulme@ed.ac.uk
Fax: +44 131 650 4743
Tel: +44 131 650 4711

b MRC Protein Phosphorylation Unit, Division of Cell Signalling, School of Life Sciences, University of Dundee, Dundee, UK
E-mail: p.cohen@dundee.ac.uk
Fax: +44 1382 223 778
Tel: +44 1382 344 238

Abstract

The synthesis of C(4)H and C(4)Me analogues of the JNK/p38 pathway activator anisomycin, based upon an aldol or Claisen construction of the C(3)–C(4) bond, has been demonstrated. The relative activation of the JNK/SAPK1 and p38/SAPK2 pathways in RAW macrophages by these analogues, and their synthetic precursors, has been assessed using immunoblot assays against phosphorylated c-Jun and MAPKAP-K2. These studies demonstrate that some of the synthetic C(4) analogues are also potent activators of these stress kinase pathways.

Graphical abstract: Synthetic anisomycin analogues activating the JNK/SAPK1 and p38/SAPK2 pathways

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Article information

DOI
https://doi.org/10.1039/B311242J
Article type
Paper
Submitted
15 Sep 2003
Accepted
21 Nov 2003
First published
02 Dec 2003

Org. Biomol. Chem., 2004,2, 142-149

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Synthetic anisomycin analogues activating the JNK/SAPK1 and p38/SAPK2 pathways

E. M. Rosser, S. Morton, K. S. Ashton, P. Cohen and A. N. Hulme, Org. Biomol. Chem., 2004, 2, 142 DOI: 10.1039/B311242J

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