Issue 20, 2004

Convenient magnesiation of aromatic and heterocyclic rings bearing a hydroxy group in presence of LiCl

Abstract

The reaction of various iodophenols with MeMgCl in presence of LiCl followed by the addition of i-PrMgCl provides the corresponding magnesiated magnesium phenolates as THF soluble reagents; this approach can be extended to heterocyclic compounds bearing a hydroxy group like pyridines and quinolines.

Graphical abstract: Convenient magnesiation of aromatic and heterocyclic rings bearing a hydroxy group in presence of LiCl

Supplementary files

Article information

Article type
Communication
Submitted
25 Jun 2004
Accepted
26 Jul 2004
First published
26 Aug 2004

Chem. Commun., 2004, 2288-2289

Convenient magnesiation of aromatic and heterocyclic rings bearing a hydroxy group in presence of LiCl

F. Kopp, A. Krasovskiy and P. Knochel, Chem. Commun., 2004, 2288 DOI: 10.1039/B409664A

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