Issue 38, 2007
From the journal:

Journal of Materials Chemistry

A new biodegradable bone wax substitute with the potential to be used as a bone filling material†

Bettina Hoffmann,*a   Elias Volkmer,*b   Andreas Kokott,a   Markus Weber,a   Sabine Hamisch,a   Matthias Schieker,b   Wolf Mutschlerb  and  Günter Zieglera  

* Corresponding authors

a Friedrich-Baur-Research Institute for Biomaterials, University of Bayreuth, Ludwig-Thoma-Str. 36c, Bayreuth, Germany
E-mail: bettina.hoffmann@fbi-biomaterialien.de
Fax: +49 (0)921-555589
Tel: +49 (0)921 555593

b Experimental Surgery and Regenerative Medicine, Department of Surgery, University of Munich (LMU), Nussbaumstr. 20, München, Germany
E-mail: elias.volkmer@med.uni-muenchen.de
Fax: +49 (0)89 5160 5482
Tel: +49 (0)89 5160 5488

Abstract

A novel biomaterial consisting of the biodegradable compounds hydroxyapatite, chitosan and starch was developed. Hydroxyapatite particles were modified in a layer-to-layer reaction with oxidised starch and deacetylated chitosan. In this manner, two kinds of particles with different surfaces were generated, one featuring deacetylated chitosan, the other one exhibiting oxidised starch at the outermost layer. Mixed together, these two kinds of particles form a homogeneous powder, which can be transformed into a paste by adding water. In contact with water the amino groups of deacetylated chitosan and the aldehyde groups of oxidised starch form a Schiff's base bonding the particles together. Particle size distribution of powder modified with polysaccharides was characterised by using a CILAS granulometer. Burn-out experiments carried out by TG-MS provided the organic/inorganic ratio. The morphology of the particles was analysed by SEM. The cytotoxicity of the new composite was examined in vitro by culturing MC3T3 mouse fibroblasts directly on the new material. The viability of MC3T3 cells was largely unaffected, and cells proliferated well on the surface of the new substance indicating excellent biocompatibility. In view of its mechanical stability, the new composite may also be used as a bone filling material in orthopedic surgery.

Graphical abstract: A new biodegradable bone wax substitute with the potential to be used as a bone filling material

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Article information

DOI
https://doi.org/10.1039/B707992N
Article type
Paper
Submitted
25 May 2007
Accepted
12 Jul 2007
First published
25 Jul 2007

J. Mater. Chem., 2007,17, 4028-4033

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A new biodegradable bone wax substitute with the potential to be used as a bone filling material

B. Hoffmann, E. Volkmer, A. Kokott, M. Weber, S. Hamisch, M. Schieker, W. Mutschler and G. Ziegler, J. Mater. Chem., 2007, 17, 4028 DOI: 10.1039/B707992N

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