Issue 44, 2007
From the journal:

Chemical Communications

Activity-based fluorescent reporters for monoamine oxidases in living cells†

Aaron E. Albers,a   Katherine A. Rawlsa  and  Christopher J. Chang*a  

* Corresponding authors

a Department of Chemistry, University of California, Berkeley, CA 94720, USA
E-mail: chrischang@berkeley.edu
Fax: (1) 510 642 7301
Tel: (1) 510 642 4704

Abstract

Monoamine Oxidase Reporters 1 and 2 (MR1 and MR2) are substrate-tethered activity probes that utilize a tandem amine oxidation/β-elimination mechanism to detect MAO chemistry in vitro and in living cells directly and specifically without the need for additional enzymes or other activating reagents.

Graphical abstract: Activity-based fluorescent reporters for monoamine oxidases in living cells

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Article information

DOI
https://doi.org/10.1039/B713190A
Article type
Communication
Submitted
28 Aug 2007
Accepted
26 Sep 2007
First published
09 Oct 2007

Chem. Commun., 2007, 4647-4649

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Activity-based fluorescent reporters for monoamine oxidases in living cells

A. E. Albers, K. A. Rawls and C. J. Chang, Chem. Commun., 2007, 4647 DOI: 10.1039/B713190A

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