Issue 29, 2006
From the journal:

Chemical Communications

Direct evidence for enzyme persulfide and disulfide intermediates during 4-thiouridine biosynthesis†

Chapman M. Wright,a   Glenn D. Christman,a   Ann M. Snellinger,a   Murray V. Johnstona  and  Eugene G. Mueller*a  

* Corresponding authors

a Department of Chemistry and Biochemistry, University of Delaware, Newark
E-mail: emueller@udel.edu
Fax: +1 302 831 6335

Abstract

Two proposed mechanisms for 4-thiouridine generation share key cysteine persulfide and disulfide intermediates, and indirect evidence of their existence has been previously reported; chemical trapping and mass spectrometry have now provided direct and definitive evidence of these key intermediates.

Graphical abstract: Direct evidence for enzyme persulfide and disulfide intermediates during 4-thiouridine biosynthesis

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Article information

DOI
https://doi.org/10.1039/B604040C
Article type
Communication
Submitted
20 Mar 2006
Accepted
31 May 2006
First published
14 Jun 2006

Chem. Commun., 2006, 3104-3106

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Direct evidence for enzyme persulfide and disulfide intermediates during 4-thiouridine biosynthesis

C. M. Wright, G. D. Christman, A. M. Snellinger, M. V. Johnston and E. G. Mueller, Chem. Commun., 2006, 3104 DOI: 10.1039/B604040C

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