Issue 32, 2009
From the journal:

Dalton Transactions

Bismuth(iii) 5-sulfosalicylate complexes: structure, solubility and activity against Helicobacter pylori†

Philip C. Andrews,*a   Glen B. Deacon,a   Richard. L. Ferrero,b   Peter C. Junk,a   Abdulgader Karrar,b   Ish Kumara  and  Jonathan G. MacLellana  

* Corresponding authors

a School of Chemistry, Monash University, Clayton, Melbourne, Vic. 3800, Australia
E-mail: phil.andrews@sci.monash.edu.au
Fax: +61 3 9905 4597
Tel: +61 3 9905 5509

b Department of Microbiology, Monash University, Clayton, Melbourne, Vic. 3800, Australia

Abstract

Treatment of 5-sulfosalicylic acid (H3Ssal) with BiPh3 results in the formation of the first dianionic carboxylate–sulfonate bismuth complex, [PhBi(HSsal)H2O]∞1a, and its ethanol analogue [PhBi(HSsal)EtOH]∞1b (space groupP21/c), while Bi(OAc)3 gives the mixed monoanionic and dianionic complex, {[Bi(HSsal)(H2Ssal)(H2O)3]2·2H2O}∞2 (space groupP[1 with combining macron]). The three complexes are all polymeric in the solid state as determined by single crystal X-ray diffraction, with extended frameworks constructed from dimeric [Bi(HSsal)]2, 1a and 1b, or from [Bi(HSsal)(H2Ssal)]2 units, 2. The heteroleptic bismuth complexes 1a and 2 display remarkable aqueous solubility, 10 and 2.5 mg ml−1 respectively, resulting in a clear solution of pH 1.5. In contrast, 1b is essentially insoluble in aqueous environments. All three complexes show significant activity against the bacterium Helicobacter pylori of <6.25 μg ml−1.

Graphical abstract: Bismuth(iii) 5-sulfosalicylate complexes: structure, solubility and activity against Helicobacter pylori

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Article information

DOI
https://doi.org/10.1039/B900774A
Article type
Paper
Submitted
14 Jan 2009
Accepted
08 May 2009
First published
25 Jun 2009

Dalton Trans., 2009, 6377-6384

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Bismuth(III) 5-sulfosalicylate complexes: structure, solubility and activity against Helicobacter pylori

P. C. Andrews, G. B. Deacon, Richard. L. Ferrero, P. C. Junk, A. Karrar, I. Kumar and J. G. MacLellan, Dalton Trans., 2009, 6377 DOI: 10.1039/B900774A

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