Issue 2, 2008
From the journal:

New Journal of Chemistry

Poly(amidoamine)s carrying TEMPO residues for NMR imaging applications

Maristella Gussoni,*a   Fulvia Greco,b   Paolo Ferruti,c   Elisabetta Ranucci,c   Alessandro Pontid  and  Lucia Zetta*b  

* Corresponding authors

a Dipartimento di Scienze e Tecnologie Biomediche, Università di Milano, Via Fratelli Cervi, 93, Segrate (MI), Italy
E-mail: maristella.gussoni@unimi.it
Fax: (+39) 0250330414

b Istituto per lo Studio delle Macromolecole, Consiglio Nazionale delle Ricerche, Via E. Bassini, 15, Milano, Italy
E-mail: lucia.zetta@ismac.cnr.it
Fax: (+39) 0223699212

c Dipartimento di Chimica Organica e Industriale, Università di Milano, Via Venezian 21, Milano, Italy

d Istituto di Scienze e Tecnologie Molecolari, Consiglio Nazionale delle Ricerche, Via Golgi 19, Milano, Italy

Abstract

An amphoteric bio-compatible and stealth-like poly (amidoamine) named ISA23 was obtained from 2,2-bis(acrylamido)acetic acid (BAC) and 2-methylpiperazine. The partial substitution of 4-amino-2,2,6,6-tetramethylpiperidin-1-oxyl (Amino-TEMPO) for 2-methylpiperazine as co-monomer gave two new PAA-TEMPO conjugates based on ISA23: ISA23-TEMPO1 and ISA23-TEMPO2 with 10 and 40% TEMPO-carrying units per polymer chain, respectively. In this study, a thorough NMR characterization of ISA23 polymer together with NMR and ESR characterizations of the ISA23-TEMPO derivatives and a preliminary evaluation of their potential as NMR labels for imaging applications are reported. Relaxivity measurements performed on ISA23-TEMPO1 and ISA23-TEMPO2 showed relaxivities of 0.4 and 1.8 mM−1 s−1, respectively, indicating that the PAA-TEMPO adducts have a definite potential as NMR imaging contrast agents. This was confirmed by preliminary magnetic resonance imaging (MRI) determinations.

Graphical abstract: Poly(amidoamine)s carrying TEMPO residues for NMR imaging applications

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Article information

DOI
https://doi.org/10.1039/B712896G
Article type
Paper
Submitted
21 Aug 2007
Accepted
20 Sep 2007
First published
08 Oct 2007

New J. Chem., 2008,32, 323-332

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Poly(amidoamine)s carrying TEMPO residues for NMR imaging applications

M. Gussoni, F. Greco, P. Ferruti, E. Ranucci, A. Ponti and L. Zetta, New J. Chem., 2008, 32, 323 DOI: 10.1039/B712896G

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