Issue 22, 2007
From the journal:

Organic & Biomolecular Chemistry

Design and synthesis of α-helical peptides and mimetics

James Garnera  and  Margaret M. Harding*a  

* Corresponding authors

a School of Chemistry, The University of New South Wales, Sydney, Australia
E-mail: harding@unsw.edu.au
Fax: +61 2 9385 5949
Tel: +61 2 9385 5638

Abstract

The α-helix is the most abundant secondary structural element in proteins and is an important structural domain for mediating protein–protein and protein–nucleic acid interactions. Strategies for the rational design and synthesis of α-helix mimetics have not matured as well as other secondary structure mimetics such as strands and turns. This perspective will focus on developments in the design, synthesis and applications of α-helices and mimetics, particularly in the last 5 years. Examples where synthetic compounds have delivered promising biological results will be highlighted as well as opportunities for the design of mimetics of the type I α-helical antifreeze proteins.

Graphical abstract: Design and synthesis of α-helical peptides and mimetics

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Article information

DOI
https://doi.org/10.1039/B710425A
Article type
Perspective
Submitted
09 Jul 2007
First published
07 Sep 2007

Org. Biomol. Chem., 2007,5, 3577-3585

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Design and synthesis of α-helical peptides and mimetics

J. Garner and M. M. Harding, Org. Biomol. Chem., 2007, 5, 3577 DOI: 10.1039/B710425A

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