Issue 5, 2010
From the journal:

Organic & Biomolecular Chemistry

Anticancer mechanism of peptide P18 in human leukemia K562 cells

Chengkang Tang,ab   Ximing Shao,a   Binbin Sun,a   Wenli Huang,a   Feng Qiu,a   Yongzhu Chen,a   Ying-kang Shi,b   Er-yong Zhang,b   Chen Wangc  and  Xiaojun Zhao*ad  

* Corresponding authors

a Institute for Nanobiomedical Technology and Membrane Biology, West China Hospital, Sichuan University, Chengdu, China
Fax: +86-28-8516-4072
Tel: +86-28-8516-4069

b Department of Thoracic and Cardiovascular Surgery, West China Hospital, Sichuan University, Guo Xue Xiang 37, Chengdu, China

c National Center of Nanoscience and Technology, Beijing 100080, China

d Center for Biomedical Engineering, NE47-379, Massachusetts Institute of Technology, Cambridge, MA, USA
E-mail: xiaojunz@mit.edu

Abstract

Studies on the anticancer mechanism of peptide P18 in human leukemia K562 cells revealed that P18 causes the death of most K562 cells by depolarizing plasma membrane potential and enhancing membrane permeability, rather than activating the classical apoptosis pathway. The mechanistic studies indicate that disrupting plasma membrane is an effective approach to kill cancer cells and help design more effective peptide analogues in future cancer therapies.

Graphical abstract: Anticancer mechanism of peptide P18 in human leukemia K562 cells

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Article information

DOI
https://doi.org/10.1039/B920762G
Article type
Communication
Submitted
05 Oct 2009
Accepted
11 Dec 2009
First published
07 Jan 2010

Org. Biomol. Chem., 2010,8, 984-987

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Anticancer mechanism of peptide P18 in human leukemia K562 cells

C. Tang, X. Shao, B. Sun, W. Huang, F. Qiu, Y. Chen, Y. Shi, E. Zhang, C. Wang and X. Zhao, Org. Biomol. Chem., 2010, 8, 984 DOI: 10.1039/B920762G

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