Issue 12, 2010
From the journal:

Organic & Biomolecular Chemistry

A nitroenolate approach to the synthesis of 4,5-disubstituted-2-aminoimidazoles. Pilot library assembly and screening for antibiotic and antibiofilm activity†

Zhaoming Su,a   Steven A. Rogers,a   W. Steve McCall,a   Alicia C. Smith,a   Sindhu Ravishankar,a   Trey Mullikina  and  Christian Melander*a  

* Corresponding authors

a Department of Chemistry, North Carolina State University, Raleigh, USA
E-mail: Christian_Melander@ncsu.edu
Tel: 1-919-513-2960

Abstract

A library of 4,5-disubstituted-2-aminoimidazoles was synthesized using a nitroenolate route and then screened for antibiofilm and antimicrobial activity. These compounds displayed notable biofilm dispersal and planktonic microbicidal activity against various Gram-positive and Gram-negative bacteria.

Graphical abstract: A nitroenolate approach to the synthesis of 4,5-disubstituted-2-aminoimidazoles. Pilot library assembly and screening for antibiotic and antibiofilm activity

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Article information

DOI
https://doi.org/10.1039/C001479F
Article type
Paper
Submitted
22 Jan 2010
Accepted
30 Mar 2010
First published
29 Apr 2010

Org. Biomol. Chem., 2010,8, 2814-2822

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A nitroenolate approach to the synthesis of 4,5-disubstituted-2-aminoimidazoles. Pilot library assembly and screening for antibiotic and antibiofilm activity

Z. Su, S. A. Rogers, W. S. McCall, A. C. Smith, S. Ravishankar, T. Mullikin and C. Melander, Org. Biomol. Chem., 2010, 8, 2814 DOI: 10.1039/C001479F

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