Issue 11, 2010
From the journal:

Soft Matter

Lipase-supported synthesis of peptidic hydrogels

Laura Chronopoulou,a   Silvia Lorenzoni,a   Giancarlo Masci,a   Mariella Dentini,a   Anna Rita Togna,b   Giuseppina Togna,b   Federico Bordic  and  Cleofe Palocci*a  

* Corresponding authors

a Department of Chemistry, Sapienza Università of Rome, Piazzale Aldo Moro 5, Rome, Italy
E-mail: cleofe.palocci@uniroma1.it

b Department of Physiology and Pharmacology “Vittorio Ersparmer”, Sapienza Università of Rome, Piazzale Aldo Moro 5, Rome, Italy

c Department of Physics, Sapienza Università of Rome, Piazzale Aldo Moro 5, Rome, Italy

Abstract

Self-assembling gelling peptides are increasingly being investigated as defined biomatrices for biomedical applications. Using an enzymatic reaction to convert a precursor into a hydrogelator one can control or modulate functions and responses of a hydrogel, depending on its preparation conditions. This work details the self-assembly, under physiological conditions, of amphiphilic building blocks consisting of tripeptides (Phe3) linked to fluorenylmethoxycarbonyl (Fmoc) obtained by using a lipase to link an Fmoc–Phe amino acid to the dipeptide diphenylalanine (Phe2). The viscoelastic properties of the tripeptides obtained were investigated. SEM and AFM images of Fmoc–peptides confirmed that they self-assemble to generate supramolecular aggregates driven by π–π stacking interactions of the Fmoc groups.

Graphical abstract: Lipase-supported synthesis of peptidic hydrogels

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Article information

DOI
https://doi.org/10.1039/C001658F
Article type
Paper
Submitted
26 Jan 2010
Accepted
01 Apr 2010
First published
28 Apr 2010

Soft Matter, 2010,6, 2525-2532

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Lipase-supported synthesis of peptidic hydrogels

L. Chronopoulou, S. Lorenzoni, G. Masci, M. Dentini, A. R. Togna, G. Togna, F. Bordi and C. Palocci, Soft Matter, 2010, 6, 2525 DOI: 10.1039/C001658F

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