Issue 8, 1989

Asymmetric reduction of ketoxime O-alkyl ethers with sodium borohydride–Lewis acid

Abstract

Novel hydride agents formed by combining Lewis acids with sodium borohydride (NaBH4) reduce quantitatively ketoxime O-alkyl ethers to the corresponding optically active primary amines with high enantioselectivities (up to 95% e.e.) in the presence of chiral amino alcohols.

Article information

Article type
Paper

J. Chem. Soc., Perkin Trans. 1, 1989, 1548-1549

Asymmetric reduction of ketoxime O-alkyl ethers with sodium borohydride–Lewis acid

S. Itsuno, Y. Sakurai, K. Shimizu and K. Ito, J. Chem. Soc., Perkin Trans. 1, 1989, 1548 DOI: 10.1039/P19890001548

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