Issue 4, 2009
From the journal:

Analyst

Amphiphilic nanoassemblies for the detection of peptides and proteins using fluorescence and mass spectrometry†

Malar A. Azagarsamy,a   Andrea Gomez-Escudero,a   Volkan Yesilyurt,a   Richard W. Vachet*a  and  S. Thayumanavan*a  

* Corresponding authors

a Department of Chemistry, University of Massachusetts, Amherst, MA 01003, USA

Abstract

Amphiphilic nanostructures provide unique environments for molecules that are incompatible with the solvent to be sequestered within their interior. These internal environments provide opportunities for concentrating an analyte or transducer molecule for detection, and the functional groups within the amphiphiles provide an opportunity for incorporating specificity or selectivity toward analytes. In this review, we discuss ways in which amphiphilic assemblies can be used to detect peptides and proteins with a particular emphasis on facially amphiphilic polymers and dendrimers.

Graphical abstract: Amphiphilic nanoassemblies for the detection of peptides and proteins using fluorescence and mass spectrometry

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Article information

DOI
https://doi.org/10.1039/B818484D
Article type
Critical Review
First published
10 Mar 2009

Analyst, 2009,134, 635-649

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Amphiphilic nanoassemblies for the detection of peptides and proteins using fluorescence and mass spectrometry

M. A. Azagarsamy, A. Gomez-Escudero, V. Yesilyurt, R. W. Vachet and S. Thayumanavan, Analyst, 2009, 134, 635 DOI: 10.1039/B818484D

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