Isolation and structure of the powerful human cancer cell growth inhibitors spongistatins 4 and 5 from an African Spirastrella spinispirulifera(porifera)

George R. Pettit; Cherry L. Herald; Zbigniew A. Cichacz; Feng Gao; Jean M. Schmidt; Michael R. Boyd; Nigel D. Christie; Fred E. Boettner

doi:10.1039/C39930001805

You do not have JavaScript enabled. Please enable JavaScript to access the full features of the site or access our non-JavaScript page.

Isolation and structure of the powerful human cancer cell growth inhibitors spongistatins 4 and 5 from an African Spirastrella spinispirulifera(porifera)

George R. Pettit, Cherry L. Herald, Zbigniew A. Cichacz, Feng Gao, Jean M. Schmidt, Michael R. Boyd, Nigel D. Christie and Fred E. Boettner

Abstract

The Southwest Indian Ocean marine sponge Spirastrella spinispirulifera has been found to contain (in 10^–7% yields) two extraordinarily potent (Gl₅₀ca. 10^–8µg ml^–1) human cancer cell line inhibitors designated spongistatins 4 1d and 5 2.

Download options Please wait...

Article information

DOI: https://doi.org/10.1039/C39930001805
Article type: Paper

Download Citation

J. Chem. Soc., Chem. Commun., 1993, 1805-1807

Permissions

Request permissions

Isolation and structure of the powerful human cancer cell growth inhibitors spongistatins 4 and 5 from an African Spirastrella spinispirulifera(porifera)

G. R. Pettit, C. L. Herald, Z. A. Cichacz, F. Gao, J. M. Schmidt, M. R. Boyd, N. D. Christie and F. E. Boettner, J. Chem. Soc., Chem. Commun., 1993, 1805 DOI: 10.1039/C39930001805

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Fetching data from CrossRef.
This may take some time to load.

Journal of the Chemical Society, Chemical Communications

Isolation and structure of the powerful human cancer cell growth inhibitors spongistatins 4 and 5 from an African Spirastrella spinispirulifera(porifera)

Abstract

Article information

Download Citation

Permissions

Isolation and structure of the powerful human cancer cell growth inhibitors spongistatins 4 and 5 from an African Spirastrella spinispirulifera(porifera)

Search articles by author

Spotlight

Advertisements