Issue 11, 2002
From the journal:

Chemical Communications

The total synthesis of alkaloids (−)-histrionicotoxin 259A, 285C and 285E†

Catherine J. Smith,a   Andrew B. Holmes*a  and  Neil J. Pressb  

* Corresponding authors

a Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, UK
E-mail: abh1@cus.cam.ac.uk

b Novartis Horsham Research Centre, Wimblehurst Road, West Sussex, Horsham, UK

Abstract

The first total syntheses of three “unsymmetrical” (i.e. different terminal groups in the side chains) members of the histrionicotoxin family of alkaloids have been accomplished via stepwise introduction of the two side chain moieties onto a common tricyclic core.

Graphical abstract: The total synthesis of alkaloids (−)-histrionicotoxin 259A, 285C and 285E

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Article information

DOI
https://doi.org/10.1039/B111514F
Article type
Communication
Submitted
18 Dec 2001
Accepted
26 Feb 2002
First published
03 May 2002

Chem. Commun., 2002, 1214-1215

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The total synthesis of alkaloids (−)-histrionicotoxin 259A, 285C and 285E

C. J. Smith, A. B. Holmes and N. J. Press, Chem. Commun., 2002, 1214 DOI: 10.1039/B111514F

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