Issue 19, 2004
From the journal:

Chemical Communications

Unsaturated 1,2-amino alcohols and ethers from aziridines and organolithiums

David M. Hodgson,*a   Bogdan Štefane,a   Timothy J. Milesa  and  Jason Witheringtonb  

* Corresponding authors

a Department of Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford, UK
E-mail: david.hodgson@chem.ox.ac.uk

b GlaxoSmithKline, New Frontiers Science Park, Third Avenue, Harlow, UK

Abstract

Organolithium-induced ring-opening of aziridines of 2,5-dihydrofuran (5 and 8) and 1,4-dimethoxybut-2-ene (16, 17 and 23) gives 3-substituted 2-aminobut-3-en-1-ols 9–15 and amino ethers 18–20 and 24–26.

Graphical abstract: Unsaturated 1,2-amino alcohols and ethers from aziridines and organolithiums

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Article information

DOI
https://doi.org/10.1039/B409486G
Article type
Communication
Submitted
24 Jun 2004
Accepted
20 Jul 2004
First published
24 Aug 2004

Chem. Commun., 2004, 2234-2235

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Unsaturated 1,2-amino alcohols and ethers from aziridines and organolithiums

D. M. Hodgson, B. Štefane, T. J. Miles and J. Witherington, Chem. Commun., 2004, 2234 DOI: 10.1039/B409486G

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