Design, synthesis and DNA-cleaving efficiency of photoswitchable dimeric azobenzene-based C2-symmetric enediynes

Amit Basak; Debarati Mitra; Moumita Kar; Kumar Biradha

doi:10.1039/B801644E

You do not have JavaScript enabled. Please enable JavaScript to access the full features of the site or access our non-JavaScript page.

Design, synthesis and DNA-cleaving efficiency of photoswitchable dimeric azobenzene-based C₂-symmetric enediynes†

Amit Basak,*^a Debarati Mitra,^a Moumita Kar^a and Kumar Biradha^a

Author affiliations

* Corresponding authors

^a Bioorganic Laboratory, Department of Chemistry, Indian Institute of Technology, Kharagpur, India
E-mail: absk@chem.iitkgp.ernet.in
Fax: +91 3222 282252
Tel: +91 322 283300

Abstract

Designed azobenzene-based enediyne-amino acid C₂-symmetric hybrids have been synthesized and the role of amino acid linker in stabilizing the Z form has been demonstrated; DNA-binding and cleavage studies have established higher reactivity of the Z-isomers.

Download options Please wait...

Supplementary files

Article information

DOI: https://doi.org/10.1039/B801644E
Article type: Communication
Submitted: 30 Jan 2008
Accepted: 28 Mar 2008
First published: 25 Apr 2008

Download Citation

Chem. Commun., 2008, 3067-3069

Permissions

Request permissions

Design, synthesis and DNA-cleaving efficiency of photoswitchable dimeric azobenzene-based C₂-symmetric enediynes

A. Basak, D. Mitra, M. Kar and K. Biradha, Chem. Commun., 2008, 3067 DOI: 10.1039/B801644E

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Social activity

Fetching data from CrossRef.
This may take some time to load.

Chemical Communications