Programing the formation of DNA and PNA quadruplexes by π–π-stacking interactions

Sourav Saha; Jianfeng Cai; Daniel Eiler; Andrew D. Hamilton

doi:10.1039/B915955J

You do not have JavaScript enabled. Please enable JavaScript to access the full features of the site or access our non-JavaScript page.

Programing the formation of DNA and PNA quadruplexes by π–π-stacking interactions†

Sourav Saha,^a Jianfeng Cai,^a Daniel Eiler^a and Andrew D. Hamilton*^a

Author affiliations

* Corresponding authors

^a Department of Chemistry, Yale University, 225 Prospect Street, New Haven, USA
E-mail: andrew.hamilton@yale.edu
Fax: +1 203-432-3221
Tel: +1 203-432-5570

Abstract

Guanine (G) rich G₄T₄G₄ DNA and homologous PNA strands tend to form antiparallel dimeric quadruplexes. In contrast, the same DNA strands carrying planar aromatic 5′-residues preferentially form parallel DNA quadruplex. Conformation and composition of the DNA quadruplexes can be programed by π–π-stacking interaction exerted by the 5′-residues.

Download options Please wait...

Supplementary files

CD melting and control studies, as well as syntheses and characterizations of compounds 1 and 5 as well as those of functionalized DNA and PNA strands with compounds 1 through 5 PDF (1865K)

Article information

DOI: https://doi.org/10.1039/B915955J
Article type: Communication
Submitted: 04 Aug 2009
Accepted: 17 Dec 2009
First published: 13 Jan 2010

Download Citation

Chem. Commun., 2010,46, 1685-1687

Permissions

Request permissions

Programing the formation of DNA and PNA quadruplexes by π–π-stacking interactions

S. Saha, J. Cai, D. Eiler and A. D. Hamilton, Chem. Commun., 2010, 46, 1685 DOI: 10.1039/B915955J

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Social activity

Fetching data from CrossRef.
This may take some time to load.

Chemical Communications

Programing the formation of DNA and PNA quadruplexes by π–π-stacking interactions†

Abstract

Supplementary files

Article information

Download Citation

Permissions

Programing the formation of DNA and PNA quadruplexes by π–π-stacking interactions

Social activity

Search articles by author

Spotlight

Advertisements