Issue 40, 2008
From the journal:

Journal of Materials Chemistry

Carborane-based derivatives of delocalised lipophilic cations for boron neutron capture therapy: synthesis and preliminary in vitro evaluation

Gianpiero Calabrese,a   Ana C. N. M. Gomes,a   Eugen Barbu,a   Thomas G. Nevella  and  John Tsibouklis*a  

* Corresponding authors

a Biomaterials and Drug Delivery Group, School of Pharmacy and Biomedical Sciences, University of Portsmouth, UK
E-mail: John.Tsibouklis@port.ac.uk

Abstract

Aimed towards the development and effective delivery of highly boronated antitumour agents for use in the neutron capture therapy of cancer, closo-carboranyl derivatives of Nile blue and salts of dequalinium, rhodamine-123 and tetraphenyl phosphonium incorporating nido-carborane counterions have been synthesized and characterized. A preliminary in vitro evaluation in human cell lines indicated the propensity of these agents to target tumour cells, and to deliver therapeutically relevant quantities of boron.

Graphical abstract: Carborane-based derivatives of delocalised lipophilic cations for boron neutron capture therapy: synthesis and preliminary in vitro evaluation

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Article information

DOI
https://doi.org/10.1039/B806197A
Article type
Paper
Submitted
11 Apr 2008
Accepted
10 Jul 2008
First published
01 Sep 2008

J. Mater. Chem., 2008,18, 4864-4871

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Carborane-based derivatives of delocalised lipophilic cations for boron neutron capture therapy: synthesis and preliminary in vitro evaluation

G. Calabrese, A. C. N. M. Gomes, E. Barbu, T. G. Nevell and J. Tsibouklis, J. Mater. Chem., 2008, 18, 4864 DOI: 10.1039/B806197A

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