Issue 26, 2010
From the journal:

Journal of Materials Chemistry

An acidic pH-triggered polymeric micelle for dual-modality MR and optical imaging

GuangHui Gao,a   Hyejung Heo,b   JungHee Leeb  and  DooSung Lee*a  

* Corresponding authors

a Department of Polymer Science and Engineering, Sungkyunkwan University, Suwon, South Korea
E-mail: dslee@skku.edu.
Fax: +82-31-292-8790
Tel: +82-31-290-7282

b Department of Radiology, Samsung Medical Center, School of Medicine, Sungkyunkwan University, Seoul, South Korea

Abstract

A dual-modality imaging probe was developed for magnetic resonance imaging (MRI) and optical imaging, based on a Fe3O4-encapsulated pH-responsive block copolymer, which was conjugated with a red fluorescent dye Sulforhodamine 101 (SR101). The block copolymer, containing methoxy poly(ethylene glycol) (PEG) as a hydrophilic segment and poly(β-amino ester) (PAE) with ionizable tertiary amine groups on its backbone as a pH-responsive segment, can be dissolved in response to an acidic pH environment, or form self-assembled micelles in aqueous media at the physiological pH (∼pH 7.4) due to the hydrophobic deionized PAE segment acting as a micellar core. The polymeric micelle conjugated with SR101 was found to have a red-fluorescent emission at 612 nm, a sharp pH transition of pH 6.8–7.0, indicating that it can be an ideal pH-triggered carrier in response to the acidic biological environment. Subsequently, the Fe3O4-encapsulated micelle was evaluated by dynamic light scattering (DLS), cryogenic transmission electron microscope (cryo-TEM), and pH-dependent Fe3O4 release. The confocal laser scanning microscopy (CLSM) observation demonstrated the cellular uptake of SR101-labeled polymeric micelles by breast cancer cells.

Graphical abstract: An acidic pH-triggered polymeric micelle for dual-modality MR and optical imaging

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Article information

DOI
https://doi.org/10.1039/C0JM00317D
Article type
Paper
Submitted
05 Feb 2010
Accepted
01 Apr 2010
First published
28 May 2010

J. Mater. Chem., 2010,20, 5454-5461

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An acidic pH-triggered polymeric micelle for dual-modality MR and optical imaging

G. Gao, H. Heo, J. Lee and D. Lee, J. Mater. Chem., 2010, 20, 5454 DOI: 10.1039/C0JM00317D

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