Paper

Lab Chip, 2008, 8, 1280 - 1284, DOI: 10.1039/b803753a

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On-site manipulation of single chromosomal DNA molecules by using optically driven microstructures

Kyohei Terao, Masao Washizu and Hidehiro Oana

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We report a novel method for manipulation of single giant DNA molecules under a video microscope. Using optically driven microstructures, we manipulated chromosomal DNA of length in the order of millimetres, extended by electroosmotic flow without DNA breakage in aqueous solution: we picked up DNA, using microfabricated hooks and wound it around microfabricated bobbins.

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