Communication

Lab Chip, 2009, 9, 38 - 40, DOI: 10.1039/b813730g

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Computer-enhanced high-throughput genetic screens of C. elegans in a microfluidic system

Matthew M. Crane, Kwanghun Chung and Hang Lu

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Most visual screens based on fluorescent markers are currently limited in throughput and accuracy. Here we present the first genetic screen of a mutagenized population of C. elegans in a microfluidic device. Animal handling streamlined by a microfluidic device and intuitive control software enabled the identification of novel mutants and a large screening speed.

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