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New Journal of Chemistry.... the home of new and emerging multidisciplinary work in the chemical sciences.
Perspective
New J. Chem., 2007, 31, 1708 - 1718, DOI: 10.1039/b710803f
Tailoring tripodal ligands for zinc sensing
Zhaohua Dai and James W. Canary
Zinc plays an important role in biological processes. It is implicated in many diseases, including those affecting the brain. Imaging zinc is becoming crucial to the elucidation of zinc concentration, distribution, kinetics and functions in cells and tissues. This review highlights recent advances in the development of picolylamine-based tripodal compounds as zinc sensors, especially our work in the field of sensing
invisible
Zn(II) using steady-state fluorescence, fluorescence lifetimes and chiroptical spectroscopy. Our approach has emphasized creative ligand design and detection schemes. Utilizing tris(2-pyridylmethyl)amine-based N4 tripodal ligands has provided a flexible system for engineering zinc sensors with improved sensitivity, selectivity and contrast. Also included are results with tripodal ligands that have focused more on applications.
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