Issue 6, 2009
From the journal:

Organic & Biomolecular Chemistry

Variation of water exchange dynamics with ligand structure and stereochemistry in lanthanide complexes based on 1,4-diazepine derivatives†

Elisa M. Elemento,a   David Parker,*a   Silvio Aime,b   Eliana Gianoliob  and  Luciano Lattuadac  

* Corresponding authors

a Department of Chemistry, Durham University, South Road, Durham, UK

b Dipartimento di Chimica IFM, Universita degli Studi di Torino, via P. Giuria 7, 10125 Turin, Italy

c Bracco Imaging s.p.a., Via E. Folli 50, 20134 Milano, Italy
E-mail: david.parker@durham.ac.uk

Abstract

Complexes of Gd, Eu and Yb(III) have been prepared with a series of heptadentate ligands related to the parent complex AAZTA, based on the 6-methyl-6-aminoperhydrodiazepine moiety. For (RR) and (RS)-diastereoisomers of a di-glutarate ligand, solution NMR studies revealed the presence of two major species that undergo water exchange rates at Gd differing by a factor of six. Comparison of solution hydration states for Eu(III) complexes reveals that each complex possesses two bound water molecules. The absence of a good correlation of 1H NMR pseudo-contact shifts for Eu and Yb analogues is suggested to arise from a change in hydration state between Eu and Yb.

Graphical abstract: Variation of water exchange dynamics with ligand structure and stereochemistry in lanthanide complexes based on 1,4-diazepine derivatives

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Article information

DOI
https://doi.org/10.1039/B818445C
Article type
Paper
Submitted
17 Oct 2008
Accepted
11 Dec 2008
First published
30 Jan 2009

Org. Biomol. Chem., 2009,7, 1120-1131

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Variation of water exchange dynamics with ligand structure and stereochemistry in lanthanide complexes based on 1,4-diazepine derivatives

E. M. Elemento, D. Parker, S. Aime, E. Gianolio and L. Lattuada, Org. Biomol. Chem., 2009, 7, 1120 DOI: 10.1039/B818445C

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