Issue 12, 1980

The crystal structure of pivaloyl-D-prolyl-L-prolyl-L-alanyl-N-methylamide

Abstract

Pivaloyl-D-prolyl-L-prolyl-L-analyl-N-methylamide (I), C19H32N4O4, crystallizes in the orthorhombic space group P212121 with four molecules in a unit cell of dimensions a= 9.982 (1), b= 10.183 (3), c= 20.746 (2)Å. The structure has been refined to R 0.048 for 1 745 observed reflections. All the peptide bonds in the molecule are trans and both the proyl residues are in the Cγ-exo-conformation. The molecule assumes a highly folded conformation in which a Type II′DL bend is followed by a Type I LL bend, both stabilised by intramolecular 4 1 hydrogen bonds. This conformation, which has been observed for the first time, is of interest in relation to the structure of gramicidin S.

Article information

Article type
Paper

J. Chem. Soc., Perkin Trans. 2, 1980, 1800-1804

The crystal structure of pivaloyl-D-prolyl-L-prolyl-L-alanyl-N-methylamide

C. M. K. Nair and M. Vijayan, J. Chem. Soc., Perkin Trans. 2, 1980, 1800 DOI: 10.1039/P29800001800

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Spotlight

Advertisements