2019 Organic Industrial Chemistry Award Winner

Dr Martin Eastgate

Dr Martin Eastgate

Bristol-Myers Squibb


Awarded for excellence in innovation in defining and developing novel processes for the synthesis of medicines.


About the Winner

Martin was born and raised in South East England. He obtained his B.Sc. from the University of Surrey, with first class honours, studying with the late Dr Roger Bolton. After completing his bachelors, Martin moved to Cambridge University to study for his Ph. D., where he worked under the guidance of Dr Stuart Warren on sulfur mediated cyclization reactions. Martin then moved to the United States to conduct Post-Doctoral research with Prof. Scott Denmark, working on the Lewis-base activation of silicon Lewis-acids. After completing his studies, Martin joined the process chemistry team at Bristol-Myers Squibb, where he is currently Group Director, Head of Chemical Research in Chemical and Synthetic Development (CSD). Martin has published over 70 papers, is named as an inventor on 15 patents and has given more than 70 lectures at conferences and universities world-wide. He is responsible for coordinating the BMS-Scripps collaboration for CSD, along with overseeing early phase project strategy and small molecule commercial route selection within CSD.

Martin has worked on numerous projects, leading teams to deliver new routes to complex molecules - such as the JAK2 inhibitor BMS-911543, the HIV attachment inhibitor Fostemsavir, the CCR2 inhibitor BMS-741672 and its analogues, and the cytotoxins Doucarmycin and Tubulysin. In addition, Martin collaborates extensively to deliver technical innovations such as a catch-release strategy for the formation/purification of macrocyclic peptides and the development of novel reagents, such as the NSP reagent for C-H imidation and, more recently, the PSI reagents for stereospecific thiophosphorylation - both in collaboration with Prof. Phil Baran and his team at Scripps. Martin is also interested in the impact of molecular complexity within industry and in the decision making process during route design, and has published several papers on strategies to leverage data analytics within this context.