Issue 26, 2009

Base and copper(i) catalyzed Mannich, alkynehydroamination cascades for the direct synthesis of 2-methylenepyrrolidines

Abstract

An efficient, simple-to-perform, one-pot reaction cascade to 2-methylenepyrrolidines from p-toluenesulfonyl protected imines and propargylated malonates under a combination of base and copper(I) catalysis is reported.

Graphical abstract: Base and copper(i) catalyzed Mannich, alkyne hydroamination cascades for the direct synthesis of 2-methylenepyrrolidines

Supplementary files

Article information

Article type
Communication
Submitted
20 Mar 2009
Accepted
11 May 2009
First published
01 Jun 2009

Chem. Commun., 2009, 3916-3918

Base and copper(I) catalyzed Mannich, alkyne hydroamination cascades for the direct synthesis of 2-methylenepyrrolidines

H. Wang, T. Yang, P. Xu and D. J. Dixon, Chem. Commun., 2009, 3916 DOI: 10.1039/B905629G

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