Issue 47, 2009
From the journal:

Chemical Communications

Highly enantioselective synthesis of tertiary alcohols: C2-symmetric N,N′-dioxide-Sc(iii) complex promoted direct aldol reaction of α-ketoesters and diazoacetate esters†

Fei Wang,a   Xiaohua Liu,a   Yulong Zhang,a   Lili Lina  and  Xiaoming Feng*a  

* Corresponding authors

a Key Laboratory of Green Chemistry & Technology, Ministry of Education, College of Chemistry, Sichuan University, Chengdu 610064, P. R. China
E-mail: xmfeng@scu.edu.cn
Fax: + 86 28 85418249
Tel: +86 28 85418249

Abstract

A C2-symmetric N,N′-dioxide-Sc(III) complex has been developed to promote the asymmetric catalytic aldol reaction of α-ketoesters and diazoacetate esters to afford tertiary alcohols in good yields with excellent enantioselectivities.

Graphical abstract: Highly enantioselective synthesis of tertiary alcohols: C2-symmetric N,N′-dioxide-Sc(iii) complex promoted direct aldol reaction of α-ketoesters and diazoacetate esters

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Article information

DOI
https://doi.org/10.1039/B913520K
Article type
Communication
Submitted
07 Jul 2009
Accepted
16 Oct 2009
First published
02 Nov 2009

Chem. Commun., 2009, 7297-7299

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Highly enantioselective synthesis of tertiary alcohols: C2-symmetric N,N′-dioxide-Sc(III) complex promoted direct aldol reaction of α-ketoesters and diazoacetate esters

F. Wang, X. Liu, Y. Zhang, L. Lin and X. Feng, Chem. Commun., 2009, 7297 DOI: 10.1039/B913520K

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