Although extensive theoretical and experimental research has been conducted on fluorinated fullerenes, little detailed information exists on their solubility in different solvents. However, this solubility is crucial for their processability and possible application. In this work, we predict the solubility of fluorinated C₆₀ in various polar and non-polar solvents, based on a correlation between experimentally measured solubilities for C₆₀ from the literature and theoretically predicted solubilisation energies. These solubilisation energies are predicted using the polarizable continuum model (PCM) at the ab initio Hartree–Fock 6-31+G* level of theory. In particular, the solubilities are predicted for C₆₀F_2n (n = 1–10) isomers, part of the addition route to saturnene C₆₀F₂₀. An increasing solubility is found for more polar solvents with higher degree of fluorination. With these results, we can determine the minimal fluorination degree necessary for possible solubilisation in a given solvent, and offer new perspectives to separate and purify species with different degrees of fluorination.